Clinical overview of the synucleinopathies
Identifieur interne : 004152 ( Main/Exploration ); précédent : 004151; suivant : 004153Clinical overview of the synucleinopathies
Auteurs : Maria J. Martí [Espagne] ; Eduardo Tolosa [Espagne] ; Jaume Campdelacreu [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Brain (pathology), Diagnosis, Differential, Diseases of the autonomic nervous system, Human, Humans, Lewy body dementia, Multiple system atrophy, Nerve Tissue Proteins (metabolism), Neurodegenerative Diseases (diagnosis), Neurodegenerative Diseases (pathology), Neurofibrils (pathology), Neuroglia (pathology), Neurologic Examination, Neurons (pathology), Parkinson disease, Parkinson's disease, Symptomatology, Synuclein, Synucleins, alpha-Synuclein, dementia with Lewy bodies, multiple system atrophy, pure autonomic failure.
- MESH :
- chemical , metabolism : Nerve Tissue Proteins.
- diagnosis : Neurodegenerative Diseases.
- pathology : Brain, Neurodegenerative Diseases, Neurofibrils, Neuroglia, Neurons.
- Diagnosis, Differential, Humans, Neurologic Examination, Synucleins, alpha-Synuclein.
Abstract
The term synucleinopathies is used to name a group of neurodegenerative disorders characterized by fibrillary aggregates of α‐synuclein protein in the cytoplasm of selective populations of neurons and glia. These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atrophy (MSA). Clinically, they are characterized by a chronic and progressive decline in motor, cognitive, behavioural, and autonomic functions, depending on the distribution of the lesions. Because of clinical overlap, differential diagnosis is sometimes very difficult. Parkinsonism is the predominant symptom of PD, but it can be indistinguishable from the parkinsonism of DLB and MSA. Autonomic dysfunction, which is an isolated finding in PAF, may be present in PD and DLB, but is usually more prominent and appears earlier in MSA. DLB could be the same disease as PD but with widespread cortical pathological states, leading to dementia, fluctuating cognition, and the characteristic visual hallucinations. The deposition of aggregates of synuclein in neurons and glia suggests that a common pathogenic mechanism may exist for these disorders. Even though synuclein may play an important role in disease development in these disorders, in light of the different symptom complex and prognosis and management issues that characterize each disorder, we think that the term synucleinopathy has little practical value as a diagnostic term for the clinician. Clinicians should attempt to reach standard clinical diagnosis on patients, such as PD, PAF, or MSA. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10559
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The term synucleinopathies is used to name a group of neurodegenerative disorders characterized by fibrillary aggregates of α‐synuclein protein in the cytoplasm of selective populations of neurons and glia. These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atrophy (MSA). Clinically, they are characterized by a chronic and progressive decline in motor, cognitive, behavioural, and autonomic functions, depending on the distribution of the lesions. Because of clinical overlap, differential diagnosis is sometimes very difficult. Parkinsonism is the predominant symptom of PD, but it can be indistinguishable from the parkinsonism of DLB and MSA. Autonomic dysfunction, which is an isolated finding in PAF, may be present in PD and DLB, but is usually more prominent and appears earlier in MSA. DLB could be the same disease as PD but with widespread cortical pathological states, leading to dementia, fluctuating cognition, and the characteristic visual hallucinations. The deposition of aggregates of synuclein in neurons and glia suggests that a common pathogenic mechanism may exist for these disorders. Even though synuclein may play an important role in disease development in these disorders, in light of the different symptom complex and prognosis and management issues that characterize each disorder, we think that the term synucleinopathy has little practical value as a diagnostic term for the clinician. Clinicians should attempt to reach standard clinical diagnosis on patients, such as PD, PAF, or MSA. © 2003 Movement Disorder Society</div>
</front>
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